Cracking the tubulin code: enzyme structures offer clues to microtubule control
- RESEARCH BRIEFINGS
Cellular structural filaments called microtubules are made up of units of tubulin proteins. Various enzymes add modifications to and remove them from tubulin units; together, these modifications form a ‘tubulin code’ that controls microtubule function. Structures of an enzyme called CCP5 reveal how it deforms tubulin tails to recognize and remove modifications called single-glutamate branches.
This is a summary of: Chen, J. et al . Tubulin code eraser CCP5 binds branch glutamates by substrate deformation. Nature 631 , 905–912 (2024) .
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doi: https://doi.org/10.1038/d41586-024-02822-7
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